What happens when a solute dissolves?
A solution is made when one substance called the solute “dissolves” into another substance called the solvent. Dissolving is when the solute breaks up from a larger crystal of molecules into much smaller groups or individual molecules. They do this by pulling away the ions and then surrounding the salt molecules.
How do you dissolve milk?
Whisk the milk powder and water together using a hand blender or mixer on low speed. Stir until the powder has completely dissolved and there is no loose powder swirling at the bottom of the bowl. Non-instant milk combines slowly, so it may take 5 minutes or longer to dissolve it completely.
Can milk dissolve in all solvent Why?
Answer: Yes because when a solvent and solute are mixed they create a solution or mixture such as milk. This works because as they solute is put in the solvent they fuse becoming one, creating a drink we all love.
What is f2 value in dissolution?
The factor f2 measures the closeness between the two profiles. An average difference of 10% at all measured time points results in a f2 value of 50. FDA has set a public standard of f2 value between 50-100 to indicate similarity between two dissolution profiles.
How do you calculate dissolution efficiency?
The dissolution efficiency (DE) is defined as the area under the dissolution curve up to a certain time (t) expressed as a percentage of the area of the rectangle described by 100% dissolution in the same time [12,13]. DE was calculated from the following equation; Where, y is the drug percent dissolved in the time t.
What is mean dissolution time?
ABSTRACT. The mean disintegration time (MDGT; mean time required for disintegration of tablets) and mean dissolution time (MDST; mean time required for drug dissolution) of water-soluble drugs from solid dosage forms were determined by moment analysis using microcalorimetric curves.
What is f1 f2 in dissolution?
The fit factors can be expressed by two approaches: f1 (the difference factor) and f2 (the similarity factor). Two dissolution profiles to be considered similar and bioequivalent, f1 should be between 0 and 15 whereas f2 should be between 50 and 1006.
What is dissolution efficiency?
Dissolution efficiency (D.E.), the area under a dissolution curve between defined time points, and the fit factors (f1 and f2) have been compared for the characterisation of dissolution profiles, using data from three batches of a product in nine different packs stored under two conditions.
Why is prednisone used in dissolution calibration?
Prednisone and Salicylic acid tablets USP were used for the calibration of dissolution test apparatus. Prednisone tablets were disintegration type and Salicylic acid tablets were non-disintegration type. Due to this, these tablets violates the quality of analytical standard.
How do you calibrate dissolution apparatus?
CALIBRATION FOR DISINTEGRATING TYPE PREDNISONE TABLETS 50 MG
- Ensure that mains of instrument and supply are “ON”.
- Set the time program for 30 minutes, temperature 37° C + 0.5° C and for 50 RPM.
- Place 900 ml of deaerated water.
- After achieving the temperature place one tablet in each bowl and start the time program.