What is Carolina trial?

What is Carolina trial?

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes.

What is Carmelina?

CARMELINA ® is a multi-national, randomized , double-blind, placebo-controlled clinical trial that involved 6,979 adults with type 2 diabetes from 27 countries at more than 600 sites observed for a median duration of 2.2 years.

What is Tecos trial?

TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Sitagliptin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control.

Which trial shows the cardio safety of glimepiride?

The CAROLINA trial (Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes) compared the effects of glimepiride, a modern sulfonylurea, and linagliptin, a dipeptidyl peptidase 4 inhibitor (14).

Is glimepiride bad for your heart?

What is the most important information I should know about glimepiride and pioglitazone? You should not use this medicine if you have severe or uncontrolled heart failure, active bladder cancer, or diabetic ketoacidosis (call your doctor for treatment). This medicine can cause or worsen congestive heart failure.

How many hours does glimepiride last?

Table 1

Class of hypoglycemic agents	Duration of action	Dosage
Glipizide	6–12 hours	2.5–20 mg twice a day
Gliclazide	12 hours	40–80 mg single dose 160–320
Glimepiride	Up to 24 hours	1–4 mg once 8 mg max
Meglitinides analogues	3 hours	0.5–4 mg TDS

Is glimepiride safe for kidneys?

In renal disease these metabolites summed. Although the half-life is 5-7 h, the drug can cause severe hypoglycemia that lasts more than 24 h. Its use is safe in GFR > 60 mL/min and with a reduced dose of up to 30 mL/min. In CKD stage 4 or 5 the use of glimepiride is dangerous[18].

Can you take glimepiride on an empty stomach?

Take with your first big meal of the day. If you skip your largest meal of the day when you normally take your medication, then it is recommended that you also skip Amaryl (glimepiride). Having an empty stomach and taking the medication can cause your blood sugar to become too low.

Is glimepiride a good drug?

Proper control of diabetes may also lessen your risk of a heart attack or stroke. Glimepiride belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body’s natural insulin.

What are the side effects of glimepiride 2mg?

Glimepiride side effects

• low blood sugar (hypoglycemia). Symptoms may include: trembling or shaking. nervousness or anxiety. irritability. sweating. lightheadedness or dizziness. headache. fast heart rate or palpitations. intense hunger. fatigue or tiredness.
• headache.
• nausea.
• dizziness.
• weakness.
• unexplained weight gain.

What is the safest drug for Type 2 diabetes?

Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of medicine at Case Western Reserve University’s Center for Health Care Research and Policy, in Cleveland.

Is glimepiride stronger than metformin?

Metformin was only more effective than glimepiride in controlling the levels of total cholesterol (TC, 0.33 [0.03, 0.63], P = 0.03), low-density lipoprotein (LDL, 0.35 [0.16, 0.53], P = 0.0002) and triglycerides (TG, 0.26 [0.05, 0.46], P = 0.01).

What should I eat if my sugar is high?

Here are seven foods that Powers says can help keep your blood sugar in check and make you happy and healthy to boot.

• Raw, Cooked, or Roasted Vegetables. These add color, flavor, and texture to a meal.
• Greens.
• Flavorful, Low-calorie Drinks.
• Melon or Berries.
• Whole-grain, Higher-fiber Foods.
• A Little Fat.
• Protein.

Does glimepiride make you gain weight?

Weight gain is considered to be a disadvantage of sulphonylurea (SU) therapy; however, previous studies suggest that glimepiride has a weight-neutral effect on patients with Type 2 diabetes [4, 5].

Why pioglitazone is banned?

The decision by the Indian government to suspend the manufacture, sale, and distribution of pioglitazone, citing concerns over adverse effects, particularly bladder cancer, came out of the blue last month, and was widely criticized by doctors and others there, as reported by Medscape Medical News.

Is it safe to take pioglitazone?

Pioglitazone is usually safe to take for a long time. Your doctor will give you regular tests to check whether it’s OK for you to continue taking it. Older people are slightly more likely to get some of the less common side effects of pioglitazone, such as heart failure.

Which is better metformin or pioglitazone?

At endpoint, pioglitazone was significantly more effective than metformin in improving indicators of insulin sensitivity, as determined by reduction of fasting serum insulin (P = 0.003) and by analysis of homeostasis model assessment for insulin sensitivity (HOMA-S; P = 0.002).

Are grapes bad for a diabetic?

A 2013 study published in the British Medical Journal concluded that the consumption of whole fruits, apples, blueberries, and grapes is significantly associated with a lower risk of developing type 2 diabetes.

What fruit should diabetics avoid?

Fruit is also an important source of vitamins, minerals, and fiber. However, fruit can also be high in sugar. People with diabetes must keep a watchful eye on their sugar intake to avoid blood sugar spikes….Fruits high in carbohydrates.

Food	Carb content
1 serving of dried fruit	20 g

What vegetables should diabetics avoid?

The Worst Vegetables for People with Diabetes

• Potatoes. Potatoes are America’s favorite vegetable; unfortunately, they also are a high glycemic food best left off the plate for people with diabetes.
• Corn.
• Peas.
• Butternut Squash.
• Vegetable Juice.
• Broccoli.
• Cabbage.
• Asparagus.

What fruit has the most sugar?

Figs are the most sugar-dense fruit we found, with approximately 8 grams of sugar in just one medium-sized fig. A serving of figs usually amounts to four of the wrinkly fruits — meaning that you’d be consuming 32 grams of sugar total in your serving.

Which is the most tastiest fruit?

Top 10 Most Delicious and Tastiest Fruits in the World

• Mango. “The king of the fruits,” mango is one of the most popular, nutritionally rich fruits with unique flavor, fragrance, taste, and heath promoting qualities.
• Strawberries.
• Watermelon.
• Pineapple.
• Orange.
• Grape.
• Apple.
• Pomegranate.

Which fruit is the healthiest?

Here are the 20 healthiest fruits on earth.

1. Grapefruit. Share on Pinterest.
2. Pineapple. Among the tropical fruits, pineapple is a nutrition superstar.
3. Avocado. Avocado is different from most other fruits.
4. Blueberries. Blueberries have powerful health benefits.
5. Apples.
6. Pomegranate.
7. Mango.
8. Strawberries.

What is a good breakfast for prediabetes?

5 Easy, Healthy Breakfast Ideas for Prediabetes

• Greek-Style Scrambled Eggs. This healthy breakfast has plenty of protein to keep energy up without spiking blood sugar.
• Overnight Spiced Peanut Butter Oatmeal.
• Superfoods Breakfast Bowl.
• Cereal and Yogurt.
• Cottage Cheese Roll-Up.

How many eggs can a diabetic have in a day?

The findings suggest that eating two eggs per day, 6 days a week can be a safe part of a healthy diet for people with type 2, according to Nicholas Fuller, PhD, from the Boden Institute Clinical Trials Unit, University of Sydney, Australia.

What fruit is good for prediabetes?

Prediabetes Diet Plan and Eating Healthier

Foods to Choose: nutrients for prediabetes	Examples
Fruit: * fiber, potassium	Peaches; cantaloupe; berries; apples; pears; oranges; tangerines; watermelon; frozen fruit (no sugar added)

Are eggs OK for prediabetes?

Eggs are a versatile food and a great source of protein. The American Diabetes Association considers eggs an excellent choice for people with diabetes. That’s primarily because one large egg contains about half a gram of carbohydrates, so it’s thought that they aren’t going to raise your blood sugar.

What 3 drinks are bad for diabetics?

Sugary drinks add little if any nutritional value to your diet.

• Regular soda. Soda takes the top spot on the list of drinks to avoid.
• Energy drinks. Energy drinks can be high in both caffeine and carbohydrates.
• Sweetened or unsweetened fruit juices.

Is banana good for diabetes?

For most people with diabetes, fruits (including bananas) are a healthy choice. Although, if you’re following a low carb diet to manage your diabetes, even a small banana contains around 22 grams of carbs, which may be too much for your eating plan.

Should diabetics eat cheese?

Cheese is often high in fat and salt but eating it in moderation is safe for someone who has diabetes. Some cheeses, especially those that are fresh, can even help reduce the risk of diabetes in people who do not already have the condition.