Can AA and AA get married?
Can AA and AA get married?
In terms of compatibility, someone with an AA genotype can marry anybody. It is safe for someone with AS to marry someone with AA genotype. Two sickle cells should not even have a relationship or get married. Individuals with the AA genotype should help you prevent genetic abnormalities by marrying the AS, AC, and SS.
Can as genotype change to AA?
The answer is yes. However, this only happens in a single cell on a rare basis. So a person with blood type AS will still have most of the cells in their body in genotype AS. Even though one cell will give rise to other cells with the AA genotype, the genotype of the person will still be AS.
Can genotype results wrong?
Genotype results may be incorrect or misinterpreted in 1% of patients. Retesting and consultation is important if doubt exists.
Which genotype is more prone to malaria?
Children with genotype AA (92.3%) were more susceptible to malaria parasite than AS (5.1%) and SS (2.6%). The association of haemoglobin genotype with malaria was highly significant (p<0.001).
Can a white person have sickle cell?
Yes, they can. Sickle cell disease can affect people of ANY race or ethnicity. Sickle cell disease, an inherited disorder of the red blood cells, is more common in African Americans in the U.S. compared to other ethnicities—occurring in approximately 1 in 365 African Americans.
Is Sickle cell disease more common in males or females?
Although no particular gender predilection has been shown in most series, analysis of the data from the US Renal Data System demonstrated marked male predominance of sickle cell nephropathy in affected patients.
Can you give blood if you have sickle cell trait?
If you have sickle cell trait, you are still are able to donate blood. There is no evidence to suggest that donating blood causes any additional risk of harm or injury to people with sickle cell trait.
Why is sickle cell disease more common in Africa?
The sickle hemoglobin mutation reached polymorphic frequency in areas of Africa—other origins of the HbS gene were in the Middle East and Indian subcontinent—where malaria was prevalent, as carriers have a survival advantage and are more likely to survive to reproduce.
What country has the most sickle cell disease?
Sickle Cell Disease (SCD), the most common blood disorder in the world, requires daily care and can cause major problems and long-term disability. Africa has the highest prevalence rates, with 20 – 30% in countries such as Nigeria, Cameroon, Republic of Congo, Gabon and Ghana.
Who is most at risk for sickle cell anemia?
Risk Factors Sickle cell disease is more common in certain ethnic groups, including: People of African descent, including African-Americans (among whom 1 in 12 carries a sickle cell gene) Hispanic-Americans from Central and South America. People of Middle Eastern, Asian, Indian, and Mediterranean descent.
Is Sickle Cell only in black?
Sickle cell disease affects blacks almost exclusively. About 10% of blacks in the United States have one copy of the gene for sickle cell disease (that is, they have sickle cell trait).
